› 6eie

X-ray diffraction
2.72Å resolution

Ras guanine nucleotide exchange factor SOS2 (Rem-cdc25), with surface mutations

Released:
DOI: 10.2210/pdb6eie/pdb
PDB entry 6eie coloured by chain, front view.
PDB entry 6eie coloured by chain, side view.
PDB entry 6eie coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Hillig RC, Sautier B, Schroeder J, Moosmayer D, Hilpmann A, Stegmann CM, Werbeck ND, Briem H, Boemer U, Weiske J, Badock V, Mastouri J, Petersen K, Siemeister G, Kahmann JD, Wegener D, Böhnke N, Eis K, Graham K, Wortmann L, von Nussbaum F, Bader B
Proc Natl Acad Sci U S A 116 2551-2560 (2019)
PMID: 30683722

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170562 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Son of sevenless homolog 2 Chain: A
Molecule details ›
Chain: A
Length: 490 amino acids
Theoretical weight: 57.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07890 (Residues: 562-1047; Coverage: 37%)
Gene name: SOS2
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, DESY BEAMLINE P11
Spacegroup: P43
Unit cell:
a: 53.97Å b: 53.97Å c: 183.793Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.218 0.285
Expression system: Escherichia coli

Quick links

Citations

78 review citations

RAS-targeted therapies: is the undruggable drugged?
Moore et al. (2020)
77 more

3 mentions without citation

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Hillig et al. (2019)
2 more