› 6eqc

Electron Microscopy
7.4Å resolution

Cryo-EM reconstruction of a complex of a binding protein and human adenovirus C5 hexon

Released:
DOI: 10.2210/pdb6eqc/pdb
PDB entry 6eqc coloured by chain, front view.
PDB entry 6eqc coloured by chain, side view.
PDB entry 6eqc coloured by chain, top view.
Source organisms:
Primary publication:
Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.
Schmid M, Ernst P, Honegger A, Suomalainen M, Zimmermann M, Braun L, Stauffer S, Thom C, Dreier B, Eibauer M, Kipar A, Vogel V, Greber UF, Medalia O, Plückthun A
Nat Commun 9 450 (2018)
PMID: 29386504
Related structures: EMD-3821

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208978 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hexon protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 952 amino acids
Theoretical weight: 108.04 KDa
Source organism: Human adenovirus 5
UniProt:
  • Canonical: P04133 (Residues: 1-952; Coverage: 100%)
Gene name: L3
Sequence domains:
scFv of 9C12 antibody Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 254 amino acids
Theoretical weight: 27.26 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 7.4Å
Relevant EMDB volumes: EMD-3821
Expression system: Spodoptera frugiperda

Quick links

Citations

12 review citations

Capsid and Genome Modification Strategies to Reduce the Immunogenicity of Adenoviral Vectors.
Kreppel et al. (2021)
11 more

1 mention without citation

Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.
Schmid et al. (2018)