› 6f7o

Solution NMR

NMR structure of an Odin-Sam1 stapled peptide

Released:
DOI: 10.2210/pdb6f7o/pdb
PDB entry 6f7o coloured by chain, ensemble of 20 models, front view.
PDB entry 6f7o coloured by chain, ensemble of 20 models, side view.
PDB entry 6f7o coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Sam domain-based stapled peptides: Structural analysis and interaction studies with the Sam domains from the EphA2 receptor and the lipid phosphatase Ship2.
Mercurio FA, Pirone L, Di Natale C, Marasco D, Pedone EM, Leone M
Bioorg Chem 80 602-610 (2018)
PMID: 30036816

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187710 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ankyrin repeat and SAM domain-containing protein 1A Chain: A
Molecule details ›
Chain: A
Length: 15 amino acids
Theoretical weight: 1.6 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q92625 (Residues: 745-757; Coverage: 1%)
Gene names: ANKS1, ANKS1A, KIAA0229, ODIN

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MK8 2 x MK8

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 46%
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

2 review citations

Self-Assembling Peptides: From Design to Biomedical Applications.
La Manna et al. (2021)
1 more

2 mentions without citation

Stapled Peptides Inhibitors: A New Window for Target Drug Discovery.
Ali et al. (2019)
1 more