6ff4

Electron Microscopy
3.4Å resolution

human Bact spliceosome core structure

Released:

Function and Biology Details

Reactions catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 28-mer (preferred)
PDBe Complex ID:
PDB-CPX-301293 (preferred)
Entry contents:
24 distinct polypeptide molecules
4 distinct RNA molecules
Macromolecules (28 distinct):
RNA-binding motif protein, X-linked 2 Chain: 1
Molecule details ›
Chain: 1
Length: 322 amino acids
Theoretical weight: 37.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y388 (Residues: 1-322; Coverage: 100%)
Gene names: CGI-79, RBMX2
Sequence domains: RNA recognition motif
BUD13 homolog Chain: 3
Molecule details ›
Chain: 3
Length: 619 amino acids
Theoretical weight: 70.67 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BRD0 (Residues: 1-619; Coverage: 100%)
Gene name: BUD13
Sequence domains: Pre-mRNA-splicing factor of RES complex
Splicing factor 3A subunit 2 Chain: 7
Splicing factor 3B subunit 2 Chain: 8
Pre-mRNA-processing-splicing factor 8 Chain: A
116 kDa U5 small nuclear ribonucleoprotein component Chain: B
SNW domain-containing protein 1 Chain: C
Pleiotropic regulator 1 Chain: D
Pre-mRNA-processing factor 17 Chain: E
Cell division cycle 5-like protein Chain: L
Crooked neck-like protein 1 Chain: O
Pre-mRNA-splicing factor RBM22 Chain: P
Protein BUD31 homolog Chain: Q
Spliceosome-associated protein CWC15 homolog Chain: R
Serine/arginine repetitive matrix protein 2 Chain: S
Peptidyl-prolyl cis-trans isomerase-like 1 Chain: V
Serine/arginine repetitive matrix protein 1 Chain: Y
Spliceosome-associated protein CWC27 homolog Chain: s
E3 ubiquitin-protein ligase RNF113A Chain: t
Splicing factor 3B subunit 1 Chain: u
Splicing factor 3B subunit 3 Chain: v
Splicing factor 3B subunit 5 Chain: x
PHD finger-like domain-containing protein 5A Chain: y
Splicing factor 3B subunit 6 Chain: z
U2 snRNA Chain: 2
U5 snRNA Chain: 5
U6 snRNA Chain: 6
pre mRNA Chain: Z

Ligands and Environments

No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.4Å
Relevant EMDB volumes: EMD-4255