6g6l

X-ray diffraction
2.2Å resolution

The crystal structures of Human MYC:MAX bHLHZip complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-133947 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Myc proto-oncogene protein Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 94 amino acids
Theoretical weight: 11.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01106 (Residues: 366-452; Coverage: 19%)
Gene names: BHLHE39, MYC
Sequence domains:
Structure domains: Helix-loop-helix DNA-binding domain
Protein max Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 83 amino acids
Theoretical weight: 9.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61244 (Residues: 22-103; Coverage: 51%)
Gene names: BHLHD4, MAX
Sequence domains: Helix-loop-helix DNA-binding domain
Structure domains: Helix-loop-helix DNA-binding domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P1
Unit cell:
a: 48.68Å b: 74.33Å c: 80.06Å
α: 107.12° β: 107.67° γ: 90.05°
R-values:
R R work R free
0.217 0.215 0.268
Expression system: Escherichia coli