› 6g76

X-ray diffraction
3Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193833 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase alpha-6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 307 amino acids
Theoretical weight: 35.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UK32 (Residues: 48-349; Coverage: 41%)
Gene names: RPS6KA6, RSK4
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand ANP 3 x ANP
Ligand ZN 1 x ZN
1 modified residue:
Ligand SEP 2 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 62.489Å b: 52.331Å c: 115.505Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.222 0.268
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Epigenetic modification and BRAF gene mutation in thyroid carcinoma.
Huang et al. (2021)
2 more

1 mention without citation

Development of new bioactive molecules to treat breast and lung cancer with natural myricetin and its derivatives: A computational and SAR approach.
Akash et al. (2022)