› 6gf2

Solution NMR

The structure of the ubiquitin-like modifier FAT10 reveals a novel targeting mechanism for degradation by the 26S proteasome

Released:
DOI: 10.2210/pdb6gf2/pdb
PDB entry 6gf2 coloured by chain, ensemble of 10 models, front view.
PDB entry 6gf2 coloured by chain, ensemble of 10 models, side view.
PDB entry 6gf2 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation.
Aichem A, Anders S, Catone N, Rößler P, Stotz S, Berg A, Schwab R, Scheuermann S, Bialas J, Schütz-Stoffregen MC, Schmidtke G, Peter C, Groettrup M, Wiesner S
Nat Commun 9 3321 (2018)
PMID: 30127417

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127352 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquitin D Chain: A
Molecule details ›
Chain: A
Length: 85 amino acids
Theoretical weight: 9.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15205 (Residues: 85-165; Coverage: 49%)
Gene names: FAT10, UBD
Sequence domains: Ubiquitin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications.
Vaughan et al. (2021)
3 more

6 mentions without citation

The case for FAT10 as a novel target in fatty liver diseases.
Wimalarathne et al. (2022)
5 more