› 6gk3

Electron Microscopy
3.9Å resolution

Two protofilament beta-2-microglobulin amyloid fibril

Released:
DOI: 10.2210/pdb6gk3/pdb
PDB entry 6gk3 coloured by chain, front view.
PDB entry 6gk3 coloured by chain, side view.
PDB entry 6gk3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of a β2-microglobulin fibril suggests a molecular basis for its amyloid polymorphism.
Iadanza MG, Silvers R, Boardman J, Smith HI, Karamanos TK, Debelouchina GT, Su Y, Griffin RG, Ranson NA, Radford SE
Nat Commun 9 4517 (2018)
PMID: 30375379
Related structures: EMD-0014

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-2-microglobulin form pI 5.3 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 64 amino acids
Theoretical weight: 7.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 42-105; Coverage: 65%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-0014
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Half a century of amyloids: past, present and future.
Ke et al. (2020)
9 more

5 mentions without citation

Deciphering the Structure and Formation of Amyloids in Neurodegenerative Diseases With Chemical Biology Tools.
Landrieu et al. (2022)
4 more