Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Glial cell line-derived neurotrophic factor receptor
- Glial cell line-derived neurotrophic factor receptor alpha 2
- GDNF/GAS1
- Cadherin-like
- Cystine-knot cytokine
- Transforming growth factor-beta, C-terminal
- RET, cadherin-like domain 4
- Tyrosine-protein kinase receptor Ret, cadherin like domain 3
6 more domains
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-126290 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Neurturin
Molecule details ›
Chains: A, B
Length: 102 amino acids
Theoretical weight: 11.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Transforming growth factor beta like domain
Length: 102 amino acids
Theoretical weight: 11.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q99748 (Residues: 96-197; Coverage: 57%)
Sequence domains: Transforming growth factor beta like domain
GDNF family receptor alpha-2
Molecule details ›
Chains: C, D
Length: 426 amino acids
Theoretical weight: 47.64 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Sequence domains: GDNF/GAS1 domain
Length: 426 amino acids
Theoretical weight: 47.64 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical: O00451 (Residues: 22-441; Coverage: 95%)
Sequence domains: GDNF/GAS1 domain
Extracellular cell-membrane anchored RET cadherin 120 kDa fragment
Molecule details ›
