› 6gx5

Electron Microscopy
3.2Å resolution

Narrow Pick Filament from Pick's disease brain

Released:
DOI: 10.2210/pdb6gx5/pdb
PDB entry 6gx5 coloured by chain, front view.
PDB entry 6gx5 coloured by chain, side view.
PDB entry 6gx5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of filaments from Pick's disease reveal a novel tau protein fold.
Falcon B, Zhang W, Murzin AG, Murshudov G, Garringer HJ, Vidal R, Crowther RA, Ghetti B, Scheres SHW, Goedert M
Nature 561 137-140 (2018)
PMID: 30158706
Related structures: EMD-0077

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145400 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 94 amino acids
Theoretical weight: 10.14 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P10636 (Residues: 602-695; Coverage: 12%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-0077

Quick links

Citations

110 review citations

Protein transmission in neurodegenerative disease.
Peng et al. (2020)
109 more

28 mentions without citation

Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.
Oakley et al. (2020)
27 more