6h03

Electron Microscopy
5.6Å resolution

OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX

Released:
Source organism: Homo sapiens
Related structures: EMD-0106

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 24-mer (preferred)
PDBe Complex ID:
PDB-CPX-133863 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (9 distinct):
Complement component C8 beta chain Chain: C
Molecule details ›
Chain: C
Length: 537 amino acids
Theoretical weight: 61.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07358 (Residues: 55-591; Coverage: 96%)
Gene name: C8B
Sequence domains:
Complement component C7 Chain: D
Complement component C8 gamma chain Chain: E
Molecule details ›
Chain: E
Length: 182 amino acids
Theoretical weight: 20.41 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07360 (Residues: 21-202; Coverage: 100%)
Gene name: C8G
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Complement component C8 alpha chain Chain: F
Molecule details ›
Chain: F
Length: 554 amino acids
Theoretical weight: 61.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07357 (Residues: 31-584; Coverage: 98%)
Gene name: C8A
Sequence domains:
Complement component C6 Chain: B
Molecule details ›
Chain: B
Length: 913 amino acids
Theoretical weight: 102.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P13671 (Residues: 22-934; Coverage: 100%)
Gene name: C6
Sequence domains:
Complement component C9 Chains: G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
Molecule details ›
Chains: G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
Length: 538 amino acids
Theoretical weight: 61.06 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02748 (Residues: 22-559; Coverage: 100%)
Gene name: C9
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.6Å
Relevant EMDB volumes: EMD-0106