› 6h36

X-ray diffraction
1.85Å resolution

The crystal structure of human carbonic anhydrase VII in complex with 4-(4-phenylpiperidine-1-carbonyl)benzenesulfonamide.

Released:
DOI: 10.2210/pdb6h36/pdb
Model geometry
Fit model/data
PDB entry 6h36 coloured by chain, front view.
PDB entry 6h36 coloured by chain, side view.
PDB entry 6h36 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.
Buemi MR, Di Fiore A, De Luca L, Angeli A, Mancuso F, Ferro S, Monti SM, Buonanno M, Russo E, De Sarro G, De Simone G, Supuran CT, Gitto R
Eur J Med Chem 163 443-452 (2019)
PMID: 30530195

Function and Biology Details

Reaction catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154962 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 7 Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 30.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43166 (Residues: 1-264; Coverage: 100%)
Gene name: CA7
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand FKE 1 x FKE
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21212
Unit cell:
a: 66.02Å b: 88.07Å c: 43.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.195 0.233
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Structure based exploration of mitochondrial alpha carbonic anhydrase inhibitors as potential leads for anti-obesity drug development.
Padhy et al. (2024)
10 other articles