› 6h6b

Electron Microscopy
3.4Å resolution

Structure of alpha-synuclein fibrils

Released:
DOI: 10.2210/pdb6h6b/pdb
PDB entry 6h6b coloured by chain, front view.
PDB entry 6h6b coloured by chain, side view.
PDB entry 6h6b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of alpha-synuclein fibrils.
Guerrero-Ferreira R, Taylor NM, Mona D, Ringler P, Lauer ME, Riek R, Britschgi M, Stahlberg H
Elife 7 (2018)
PMID: 29969391
Related structures: EMD-0148

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153502 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-synuclein Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 121 amino acids
Theoretical weight: 12.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P37840 (Residues: 1-121; Coverage: 86%)
Gene names: NACP, PARK1, SNCA
Sequence domains: Synuclein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-0148
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

74 review citations

Half a century of amyloids: past, present and future.
Ke et al. (2020)
73 more

19 mentions without citation

Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles.
Meade et al. (2019)
18 more