› 6hgo

X-ray diffraction
2.1Å resolution

Crystal Structure of human IL-17F

Released:
DOI: 10.2210/pdb6hgo/pdb
PDB entry 6hgo coloured by chain, front view.
PDB entry 6hgo coloured by chain, side view.
PDB entry 6hgo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Goepfert A, Lehmann S, Blank J, Kolbinger F, Rondeau JM
Immunity 52 499-512.e5 (2020)
PMID: 32187518

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188665 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Interleukin-17F Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 139 amino acids
Theoretical weight: 15.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96PD4 (Residues: 31-163; Coverage: 100%)
Gene name: IL17F
Sequence domains: Interleukin-17

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 3 x NAG
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P65
Unit cell:
a: 126.195Å b: 126.195Å c: 88.539Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.199 0.22
Expression system: Homo sapiens

Quick links

Citations

19 review citations

The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside.
Liu et al. (2020)
18 more

1 mention without citation

A New Investigation into the Molecular Mechanism of Andrographolide towards Reducing Cytokine Storm.
Alzahrani A. (2022)