› 6hin

Electron Microscopy
4.1Å resolution

Mouse serotonin 5-HT3 receptor, serotonin-bound, F conformation

Released:
DOI: 10.2210/pdb6hin/pdb
PDB entry 6hin coloured by chain, front view.
PDB entry 6hin coloured by chain, side view.
PDB entry 6hin coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Conformational transitions of the serotonin 5-HT3 receptor.
Polovinkin L, Hassaine G, Perot J, Neumann E, Jensen AA, Lefebvre SN, Corringer PJ, Neyton J, Chipot C, Dehez F, Schoehn G, Nury H
Nature 563 275-279 (2018)
PMID: 30401839
Related structures: EMD-0225

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150140 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
5-hydroxytryptamine receptor 3A Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 450 amino acids
Theoretical weight: 51.91 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P23979 (Residues: 37-303, 305-486; Coverage: 96%)
Gene names: 5ht3, Htr3, Htr3a
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 5 x NAG
Ligand SRO 5 x SRO
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-0225
Expression system: Homo sapiens

Quick links

Citations

13 review citations

Progress in nicotinic receptor structural biology.
Gharpure et al. (2020)
12 more

11 mentions without citation

Structure, dynamics and lipid interactions of serotonin receptors: excitements and challenges.
Sarkar et al. (2020)
10 more