› 6hpi

Solution NMR

NMR structure of the pro-inflammatory cytokine interleukin-36alpha

Released:
DOI: 10.2210/pdb6hpi/pdb
PDB entry 6hpi coloured by chain, ensemble of 20 models, front view.
PDB entry 6hpi coloured by chain, ensemble of 20 models, side view.
PDB entry 6hpi coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
(1)H, (13)C, and (15)N resonance assignments for the pro-inflammatory cytokine interleukin-36α.
Goradia N, Wißbrock A, Wiedemann C, Bordusa F, Ramachandran R, Imhof D, Ohlenschläger O
Biomol NMR Assign 10 329-33 (2016)
PMID: 27351892

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193731 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-36 alpha Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 17.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UHA7 (Residues: 1-158; Coverage: 100%)
Gene names: FIL1E, IL1E, IL1F6, IL36A
Sequence domains: Interleukin-1 / 18

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 83%
Refinement method: molecular dynamics
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

IL-1RAP, a Key Therapeutic Target in Cancer.
Frenay et al. (2022)
1 other article

4 mentions without citation

Viral Generated Inter-Organelle Contacts Redirect Lipid Flux for Genome Replication.
Laufman et al. (2019)
3 more