› 6hrs

X-ray diffraction
2.95Å resolution

Structure of the TRPML2 ELD at pH 4.5

Released:
DOI: 10.2210/pdb6hrs/pdb
PDB entry 6hrs coloured by chain, front view.
PDB entry 6hrs coloured by chain, side view.
PDB entry 6hrs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain.
Viet KK, Wagner A, Schwickert K, Hellwig N, Brennich M, Bader N, Schirmeister T, Morgner N, Schindelin H, Hellmich UA
Structure 27 1246-1257.e5 (2019)
PMID: 31178222

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184970 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mucolipin-2 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 199 amino acids
Theoretical weight: 23.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IZK6 (Residues: 86-284; Coverage: 35%)
Gene name: MCOLN2
Sequence domains: Mucolipin, extracytosolic domain

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P21
Unit cell:
a: 74.523Å b: 142.473Å c: 85.195Å
α: 90° β: 104.49° γ: 90°
R-values:
R R work R free
0.184 0.182 0.216
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Structural Pharmacology of TRP Channels.
Zhao et al. (2021)
6 more

7 mentions without citation

Patient-Derived Explants as a Precision Medicine Patient-Proximal Testing Platform Informing Cancer Management.
Templeton et al. (2021)
6 more