› 6hso

X-ray diffraction
1.95Å resolution

Crystal structure of the ternary complex of GephE-ADP-Glycine receptor derived peptide

Released:
DOI: 10.2210/pdb6hso/pdb
Model geometry
Fit model/data
PDB entry 6hso coloured by chain, front view.
PDB entry 6hso coloured by chain, side view.
PDB entry 6hso coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, Schindelin H
Neuron 101 673-689.e11 (2019)
PMID: 30704910

Function and Biology Details

Reactions catalysed: 
Adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP
ATP + molybdopterin = diphosphate + adenylyl-molybdopterin
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166832 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Gephyrin Chain: A
Molecule details ›
Chain: A
Length: 419 amino acids
Theoretical weight: 45.65 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03555 (Residues: 350-768; Coverage: 55%)
Gene names: Gph, Gphn
Sequence domains:
Structure domains:
Glycine receptor beta subunit derived peptide Chains: D, I
Molecule details ›
Chains: D, I
Length: 11 amino acids
Theoretical weight: 1.19 KDa
Source organism: Rattus norvegicus
Expression system: Not provided

Ligands and Environments

6 bound ligands:
Ligand MPD 2 x MPD
Ligand ACT 6 x ACT
Ligand MG 2 x MG
Ligand ADP 1 x ADP
Ligand PO4 1 x PO4
Ligand 3F7 1 x 3F7
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: I222
Unit cell:
a: 88.09Å b: 99.649Å c: 113.002Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.166 0.211
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

Looking for Novelty in an "Old" Receptor: Recent Advances Toward Our Understanding of GABAARs and Their Implications in Receptor Pharmacology.
Castellano et al. (2020)
11 other articles