› 6hv0

X-ray diffraction
2.73Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase/endoribonuclease IRE1 Chain: A
Molecule details ›
Chain: A
Length: 416 amino acids
Theoretical weight: 47.76 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75460 (Residues: 562-977; Coverage: 43%)
Gene names: ERN1, IRE1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GUK 1 x GUK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 144.04Å b: 46.05Å c: 86.34Å
α: 90° β: 112.71° γ: 90°
R-values:
R R work R free
0.218 0.212 0.269
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Chemical Chaperones to Inhibit Endoplasmic Reticulum Stress: Implications in Diseases.
Jeon et al. (2022)
2 more

2 mentions without citation

HEPN RNases - an emerging class of functionally distinct RNA processing and degradation enzymes.
Pillon et al. (2021)
1 more