› 6hvd

X-ray diffraction
1.63Å resolution

Human SLK bound to a maleimide inhibitor

Released:
DOI: 10.2210/pdb6hvd/pdb
PDB entry 6hvd coloured by chain, front view.
PDB entry 6hvd coloured by chain, side view.
PDB entry 6hvd coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Sorrell FJ, Berger BT, Salah E, Serafim RAM, Savitsky PA, Krojer T, Bailey HJ, Pinkas D, Burgess-Brown NA, von Delft F, Knapp S, Arrowsmith C, Bountra C, Edwards AM, Elkins JM

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190546 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
STE20-like serine/threonine-protein kinase Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 34.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H2G2 (Residues: 19-320; Coverage: 25%)
Gene names: KIAA0204, SLK, STK2
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand EDO 3 x EDO
Ligand GUQ 1 x GUQ
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P4122
Unit cell:
a: 69.871Å b: 69.871Å c: 164.301Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.186 0.208
Expression system: Escherichia coli

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