› 6hx1

X-ray diffraction
2.14Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase/endoribonuclease IRE1 Chain: A
Molecule details ›
Chain: A
Length: 403 amino acids
Theoretical weight: 46.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75460 (Residues: 562-964; Coverage: 42%)
Gene names: ERN1, IRE1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GXK 1 x GXK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 144.408Å b: 47.074Å c: 86.369Å
α: 90° β: 112.14° γ: 90°
R-values:
R R work R free
0.219 0.217 0.268
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Chemical Chaperones to Inhibit Endoplasmic Reticulum Stress: Implications in Diseases.
Jeon et al. (2022)
2 more

4 mentions without citation

HEPN RNases - an emerging class of functionally distinct RNA processing and degradation enzymes.
Pillon et al. (2021)
3 more