› 6i07

X-ray diffraction
2.35Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210694 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Single chain Fv Chains: A, B
Molecule details ›
Chains: A, B
Length: 262 amino acids
Theoretical weight: 27.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Epithelial cell adhesion molecule Chains: C, D
Molecule details ›
Chains: C, D
Length: 253 amino acids
Theoretical weight: 28.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P16422 (Residues: 24-265; Coverage: 83%)
Gene names: EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
1 modified residue:
Ligand PCA 2 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 80.886Å b: 91.071Å c: 181.445Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.23 0.279
Expression system: Homo sapiens

Quick links

Citations

6 review citations

Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside.
Liu et al. (2022)
5 more

3 mentions without citation

Current View on EpCAM Structural Biology.
Gaber et al. (2020)
2 more