6i68

X-ray diffraction
1.85Å resolution

Co-crystal structure of human SPOP MATH domain (M117V) and human BRD3 fragment

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-129120 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Speckle-type POZ protein Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 145 amino acids
Theoretical weight: 16.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43791 (Residues: 28-166; Coverage: 37%)
Gene name: SPOP
Sequence domains: MATH domain
Structure domains: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Bromodomain-containing protein 3 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 9 amino acids
Theoretical weight: 936 Da
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15059 (Residues: 245-253; Coverage: 1%)
Gene names: BRD3, KIAA0043, RING3L

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P21
Unit cell:
a: 44.775Å b: 90.128Å c: 88.563Å
α: 90° β: 91.17° γ: 90°
R-values:
R R work R free
0.198 0.196 0.238
Expression system: Escherichia coli BL21(DE3)