› 6i6i

X-ray diffraction
1.5Å resolution

Circular permutant of ribosomal protein S6, adding 6aa to C terminal of P68-69, L75A mutant

Released:
DOI: 10.2210/pdb6i6i/pdb
PDB entry 6i6i coloured by chain, front view.
PDB entry 6i6i coloured by chain, side view.
PDB entry 6i6i coloured by chain, top view.
Source organism: Thermus thermophilus HB8
Primary publication:
Exposing the distinctive modular behavior of β-strands and α-helices in folded proteins.
Wang H, Logan DT, Danielsson J, Oliveberg M
Proc Natl Acad Sci U S A 117 28775-28783 (2020)
PMID: 33148805

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178198 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Small ribosomal subunit protein bS6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 102 amino acids
Theoretical weight: 11.95 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q5SLP8 (Residues: 69-91, 3-74; Coverage: 88%)
Gene names: TTHA0245, rpsF

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup: C2221
Unit cell:
a: 48.651Å b: 48.659Å c: 132.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.233
Expression system: Escherichia coli BL21

Quick links

Citations

3 citation in other articles

Amyloid β Dodecamer Disrupts the Neuronal Membrane More Strongly than the Mature Fibril: Understanding the Role of Oligomers in Neurotoxicity.
Nguyen et al. (2022)
2 more