› 6i7s

X-ray diffraction
2.5Å resolution

Microsomal triglyceride transfer protein

Released:
DOI: 10.2210/pdb6i7s/pdb
PDB entry 6i7s coloured by chain, front view.
PDB entry 6i7s coloured by chain, side view.
PDB entry 6i7s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human microsomal triglyceride transfer protein.
Biterova EI, Isupov MN, Keegan RM, Lebedev AA, Sohail AA, Liaqat I, Alanen HI, Ruddock LW
Proc Natl Acad Sci U S A 116 17251-17260 (2019)
PMID: 31395737

Function and Biology Details

Reaction catalysed: 
Catalyzes the rearrangement of -S-S- bonds in proteins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139448 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein disulfide-isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 492 amino acids
Theoretical weight: 55.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P07237 (Residues: 18-508; Coverage: 100%)
Gene names: ERBA2L, P4HB, PDI, PDIA1, PO4DB
Sequence domains:
Microsomal triglyceride transfer protein large subunit Chains: G, H
Molecule details ›
Chains: G, H
Length: 884 amino acids
Theoretical weight: 98.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P55157 (Residues: 1-1, 19-894; Coverage: 98%)
Gene names: MTP, MTTP
Sequence domains:

Ligands and Environments

8 bound ligands:
Ligand CA 2 x CA
Ligand EDO 19 x EDO
Ligand PGE 6 x PGE
Ligand SO4 11 x SO4
Ligand PEG 9 x PEG
Ligand PE5 2 x PE5
Ligand TRS 1 x TRS
Ligand PE4 1 x PE4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P1
Unit cell:
a: 77.537Å b: 105.595Å c: 112.269Å
α: 89.81° β: 76.95° γ: 74.24°
R-values:
R R work R free
0.207 0.204 0.257
Expression system: Escherichia coli K-12

Quick links

Citations

4 review citations

Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target.
Behbodikhah et al. (2021)
3 more

11 mentions without citation

PDI Family Members as Guides for Client Folding and Assembly.
Kanemura et al. (2020)
10 more