› 6iaq

X-ray diffraction
1.91Å resolution

Function and Biology Details

Reaction catalysed: 
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)(+) + H(2)O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105980 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydrodipicolinate reductase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 339 amino acids
Theoretical weight: 36.49 KDa
Source organism: Mycolicibacterium smegmatis
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A8B4R7U8 (Residues: 2-335; Coverage: 100%)
Gene names: NCTC7017_05569, dapB_1
Sequence domains:

Ligands and Environments


Cofactor: Ligand NAP 4 x NAP
1 bound ligand:
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 51.39Å b: 147.91Å c: 97.78Å
α: 90° β: 98.18° γ: 90°
R-values:
R R work R free
0.202 0.2 0.233
Expression system: Escherichia coli

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