› 6iet

X-ray diffraction
2.1Å resolution

The crystal structure of TRIM66 PHD-Bromo domain

Released:
DOI: 10.2210/pdb6iet/pdb
PDB entry 6iet coloured by chain, front view.
PDB entry 6iet coloured by chain, side view.
PDB entry 6iet coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells.
Chen J, Wang Z, Guo X, Li F, Wei Q, Chen X, Gong D, Xu Y, Chen W, Liu Y, Kang J, Shi Y
Nat Commun 10 4273 (2019)
PMID: 31537782

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127262 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tripartite motif-containing protein 66 Chain: A
Molecule details ›
Chain: A
Length: 196 amino acids
Theoretical weight: 22.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15016 (Residues: 1103-1295; Coverage: 14%)
Gene names: C11orf29, KIAA0298, TRIM66
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P61
Unit cell:
a: 54.192Å b: 54.192Å c: 108.31Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.206 0.256
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

TIF1 Proteins in Genome Stability and Cancer.
McAvera et al. (2020)
7 more