› 6ige

X-ray diffraction
2.9Å resolution

Crystal structure of Human Papillomavirus type 33 pentamer

Released:
DOI: 10.2210/pdb6ige/pdb
PDB entry 6ige coloured by chain, front view.
PDB entry 6ige coloured by chain, side view.
PDB entry 6ige coloured by chain, top view.
Source organism: human papillomavirus 33
Primary publication:
Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity.
Li Z, Song S, He M, Wang D, Shi J, Liu X, Li Y, Chi X, Wei S, Yang Y, Wang Z, Li J, Qian H, Yu H, Zheng Q, Yan X, Zhao Q, Zhang J, Gu Y, Li S, Xia N
Nat Commun 9 5360 (2018)
PMID: 30560935

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139044 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major capsid protein L1 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 499 amino acids
Theoretical weight: 55.98 KDa
Source organism: human papillomavirus 33
Expression system: Escherichia coli
UniProt:
  • Canonical: P06416 (Residues: 1-499; Coverage: 100%)
Gene name: L1
Sequence domains: L1 (late) protein
Structure domains: Major capsid L1 (late) superfamily, Papillomavirus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P21
Unit cell:
a: 98.827Å b: 171.937Å c: 145.692Å
α: 90° β: 97.04° γ: 90°
R-values:
R R work R free
0.211 0.21 0.24
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Emerging Concepts and Technologies in Vaccine Development.
Brisse et al. (2020)
3 more

1 mention without citation

Comprehensive Assessment of the Antigenic Impact of Human Papillomavirus Lineage Variation on Recognition by Neutralizing Monoclonal Antibodies Raised against Lineage A Major Capsid Proteins of Vaccine-Related Genotypes.
Godi et al. (2020)