› 6igl

X-ray diffraction
2.7Å resolution

Crystal Structure of human ETB receptor in complex with IRL1620

Released:
DOI: 10.2210/pdb6igl/pdb
PDB entry 6igl coloured by chain, front view.
PDB entry 6igl coloured by chain, side view.
PDB entry 6igl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation.
Shihoya W, Izume T, Inoue A, Yamashita K, Kadji FMN, Hirata K, Aoki J, Nishizawa T, Nureki O
Nat Commun 9 4711 (2018)
PMID: 30413709

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150242 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Endothelin receptor type B Chain: A
Molecule details ›
Chain: A
Length: 498 amino acids
Theoretical weight: 55.96 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24530 (Residues: 66-303, 304-310, 311-407; Coverage: 82%)
Gene names: EDNRB, ETRB
Sequence domains: 7 transmembrane receptor (rhodopsin family)
IRL1620 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.82 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand CIT 1 x CIT
Ligand SO4 4 x SO4
Ligand OLC 3 x OLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: C2221
Unit cell:
a: 99.98Å b: 303.86Å c: 60.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.207 0.242
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

6 review citations

Capturing Peptide-GPCR Interactions and Their Dynamics.
Kaiser et al. (2020)
5 more

5 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
4 more