› 6igx

X-ray diffraction
3Å resolution

Crystal structure of human CAP-G in complex with CAP-H

Released:
DOI: 10.2210/pdb6igx/pdb
PDB entry 6igx coloured by chain, front view.
PDB entry 6igx coloured by chain, side view.
PDB entry 6igx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex.
Hara K, Kinoshita K, Migita T, Murakami K, Shimizu K, Takeuchi K, Hirano T, Hashimoto H
EMBO Rep 20 (2019)
PMID: 30858338

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172149 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Condensin complex subunit 3 Chains: B, D
Molecule details ›
Chains: B, D
Length: 839 amino acids
Theoretical weight: 94.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BPX3 (Residues: 1-900; Coverage: 81%)
Gene names: CAPG, NCAPG, NYMEL3
Sequence domains: Nuclear condensing complex subunits, C-term domain
Condensin complex subunit 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 57 amino acids
Theoretical weight: 6.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15003 (Residues: 470-526; Coverage: 8%)
Gene names: BRRN, BRRN1, CAPH, KIAA0074, NCAPH

Ligands and Environments

1 bound ligand:
Ligand EPE 1 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P21
Unit cell:
a: 122.433Å b: 61.998Å c: 130.885Å
α: 90° β: 93.47° γ: 90°
R-values:
R R work R free
0.215 0.212 0.272
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Condensin complexes: understanding loop extrusion one conformational change at a time.
Cutts et al. (2020)
3 more

1 mention without citation

Modulation of Tumor Immune Microenvironment and Prognostic Value of Ferroptosis-Related Genes, and Candidate Target Drugs in Glioblastoma Multiforme.
Zhang et al. (2022)