› 6iij

Electron Microscopy
2.84Å resolution

Cryo-EM structure of CV-A10 mature virion

Released:
DOI: 10.2210/pdb6iij/pdb
PDB entry 6iij coloured by chain, front view.
PDB entry 6iij coloured by chain, side view.
PDB entry 6iij coloured by chain, top view.
Source organism: Coxsackievirus A10
Primary publication:
Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses.
Chen J, Ye X, Zhang XY, Zhu Z, Zhang X, Xu Z, Ding Z, Zou G, Liu Q, Kong L, Jiang W, Zhu W, Cong Y, Huang Z
Cell Discov 5 4 (2019)
PMID: 30652025
Related structures: EMD-9674

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 240-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103274 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
VP1 Chain: A
Molecule details ›
Chain: A
Length: 297 amino acids
Theoretical weight: 33.09 KDa
Source organism: Coxsackievirus A10
UniProt:
  • Canonical: A0A1B3Z4Y8 (Residues: 565-861; Coverage: 35%)
Sequence domains: picornavirus capsid protein
VP2 Chain: B
Molecule details ›
Chain: B
Length: 255 amino acids
Theoretical weight: 27.74 KDa
Source organism: Coxsackievirus A10
UniProt:
  • Canonical: A0A1B3Z4Y8 (Residues: 70-324; Coverage: 30%)
Sequence domains: picornavirus capsid protein
VP3 Chain: C
Molecule details ›
Chain: C
Length: 240 amino acids
Theoretical weight: 26.19 KDa
Source organism: Coxsackievirus A10
UniProt:
  • Canonical: A0A1B3Z4Y8 (Residues: 325-564; Coverage: 28%)
Sequence domains: picornavirus capsid protein
Structure domains: Jelly Rolls
VP4 Chain: D
Molecule details ›
Chain: D
Length: 69 amino acids
Theoretical weight: 7.46 KDa
Source organism: Coxsackievirus A10
UniProt: Sequence domains: Picornavirus coat protein (VP4)

Ligands and Environments

1 bound ligand:
Ligand SPH 1 x SPH
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.84Å
Relevant EMDB volumes: EMD-9674

Quick links

Citations

1 review citation

Antivirals blocking entry of enteroviruses and therapeutic potential.
Anasir et al. (2021)
11 other articles

3 mentions without citation

Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10.
Zhao et al. (2020)
2 more