› 6iio

Electron Microscopy
3.12Å resolution

Cryo-EM structure of CV-A10 native empty particle

Released:
DOI: 10.2210/pdb6iio/pdb
PDB entry 6iio coloured by chain, front view.
PDB entry 6iio coloured by chain, side view.
PDB entry 6iio coloured by chain, top view.
Source organism: Coxsackievirus A10
Primary publication:
Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses.
Chen J, Ye X, Zhang XY, Zhu Z, Zhang X, Xu Z, Ding Z, Zou G, Liu Q, Kong L, Jiang W, Zhu W, Cong Y, Huang Z
Cell Discov 5 4 (2019)
PMID: 30652025
Related structures: EMD-9675

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 180-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103273 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
VP1 Chain: A
Molecule details ›
Chain: A
Length: 297 amino acids
Theoretical weight: 33.09 KDa
Source organism: Coxsackievirus A10
UniProt:
  • Canonical: A0A1B3Z4Y8 (Residues: 565-861; Coverage: 35%)
Sequence domains: picornavirus capsid protein
VP0 Chain: B
Molecule details ›
Chain: B
Length: 324 amino acids
Theoretical weight: 35.19 KDa
Source organism: Coxsackievirus A10
UniProt:
  • Canonical: A0A1B3Z4Y8 (Residues: 1-324; Coverage: 38%)
Sequence domains:
VP3 Chain: C
Molecule details ›
Chain: C
Length: 240 amino acids
Theoretical weight: 26.19 KDa
Source organism: Coxsackievirus A10
UniProt:
  • Canonical: A0A1B3Z4Y8 (Residues: 325-564; Coverage: 28%)
Sequence domains: picornavirus capsid protein
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.12Å
Relevant EMDB volumes: EMD-9675

Quick links

Citations

1 review citation

Antivirals blocking entry of enteroviruses and therapeutic potential.
Anasir et al. (2021)
12 other articles

1 mention without citation

An enterovirus A71 virus-like particle with replaced loops confers partial cross-protection in mice.
Liu et al. (2023)