› 6iiq

X-ray diffraction
1.85Å resolution

Complex structure of the HRP3 PWWP domain with a 16-bp TA-rich DNA

Released:
DOI: 10.2210/pdb6iiq/pdb
PDB entry 6iiq coloured by chain, front view.
PDB entry 6iiq coloured by chain, side view.
PDB entry 6iiq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Complex structure of the HRP3 PWWP domain with a 16-bp TA-rich DNA
Wang Z, Tian W
Nucleic Acids Res. (2019)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-120012 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Hepatoma-derived growth factor-related protein 3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 100 amino acids
Theoretical weight: 11.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y3E1 (Residues: 1-99; Coverage: 49%)
Gene names: CGI-142, HDGF2, HDGFL3, HDGFRP3
Sequence domains: PWWP domain
16-bp TA-rich DNA Chains: D, E, F, G
Molecule details ›
Chains: D, E, F, G
Length: 16 nucleotides
Theoretical weight: 4.89 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand MLA 3 x MLA
Ligand TRS 3 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2
Unit cell:
a: 57.426Å b: 33.556Å c: 201.151Å
α: 90° β: 90.06° γ: 90°
R-values:
R R work R free
0.207 0.205 0.253
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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