› 6ilk

Electron Microscopy
3Å resolution

Cryo-EM structure of Echovirus 6 complexed with its attachment receptor CD55 at PH 7.4

Released:
DOI: 10.2210/pdb6ilk/pdb
PDB entry 6ilk coloured by chain, front view.
PDB entry 6ilk coloured by chain, side view.
PDB entry 6ilk coloured by chain, top view.
Source organisms:
Primary publication:
Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.
Zhao X, Zhang G, Liu S, Chen X, Peng R, Dai L, Qu X, Li S, Song H, Gao Z, Yuan P, Liu Z, Li C, Shang Z, Li Y, Zhang M, Qi J, Wang H, Du N, Wu Y, Bi Y, Gao S, Shi Y, Yan J, Zhang Y, Xie Z, Wei W, Gao GF
Cell 177 1553-1565.e16 (2019)
PMID: 31104841
Related structures: EMD-9685

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 300-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139974 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 278 amino acids
Theoretical weight: 31.71 KDa
Source organism: Echovirus E6
Capsid protein VP2 Chain: B
Molecule details ›
Chain: B
Length: 252 amino acids
Theoretical weight: 28.06 KDa
Source organism: Echovirus E6
Capsid protein VP3 Chain: C
Molecule details ›
Chain: C
Length: 238 amino acids
Theoretical weight: 26.38 KDa
Source organism: Echovirus E6
Structure domains: Jelly Rolls
Capsid protein VP4 Chain: D
Molecule details ›
Chain: D
Length: 68 amino acids
Theoretical weight: 7.34 KDa
Source organism: Echovirus E6
Complement decay-accelerating factor Chain: E
Molecule details ›
Chain: E
Length: 192 amino acids
Theoretical weight: 21.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08174 (Residues: 94-285; Coverage: 55%)
Gene names: CD55, CR, DAF
Sequence domains: Sushi repeat (SCR repeat)

Ligands and Environments

1 bound ligand:
Ligand SPH 1 x SPH
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-9685
Expression system: Homo sapiens

Quick links

Citations

9 review citations

Return of the Neurotropic Enteroviruses: Co-Opting Cellular Pathways for Infection.
Peters et al. (2021)
8 more

3 mentions without citation

Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.
Zhao et al. (2019)
2 more