› 6ilm

Electron Microscopy
3.4Å resolution

Cryo-EM structure of Echovirus 6 complexed with its uncoating receptor FcRn at PH 7.4

Released:
DOI: 10.2210/pdb6ilm/pdb
PDB entry 6ilm coloured by chain, front view.
PDB entry 6ilm coloured by chain, side view.
PDB entry 6ilm coloured by chain, top view.
Source organisms:
Primary publication:
Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.
Zhao X, Zhang G, Liu S, Chen X, Peng R, Dai L, Qu X, Li S, Song H, Gao Z, Yuan P, Liu Z, Li C, Shang Z, Li Y, Zhang M, Qi J, Wang H, Du N, Wu Y, Bi Y, Gao S, Shi Y, Yan J, Zhang Y, Xie Z, Wei W, Gao GF
Cell 177 1553-1565.e16 (2019)
PMID: 31104841
Related structures: EMD-9687

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 360-mer (preferred)
PDBe Complex ID:
PDB-CPX-157348 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 289 amino acids
Theoretical weight: 32.97 KDa
Source organism: Echovirus E6
Capsid protein VP2 Chain: B
Molecule details ›
Chain: B
Length: 252 amino acids
Theoretical weight: 28.06 KDa
Source organism: Echovirus E6
Capsid protein VP3 Chain: C
Molecule details ›
Chain: C
Length: 238 amino acids
Theoretical weight: 26.38 KDa
Source organism: Echovirus E6
Structure domains: Jelly Rolls
Capsid protein VP4 Chain: D
Molecule details ›
Chain: D
Length: 68 amino acids
Theoretical weight: 7.34 KDa
Source organism: Echovirus E6
IgG receptor FcRn large subunit p51 Chain: E
Molecule details ›
Chain: E
Length: 263 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P55899 (Residues: 28-290; Coverage: 77%)
Gene names: FCGRT, FCRN
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: F
Molecule details ›
Chain: F
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand SPH 1 x SPH
Ligand K 1 x K
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-9687
Expression system: Homo sapiens

Quick links

Citations

8 review citations

Return of the Neurotropic Enteroviruses: Co-Opting Cellular Pathways for Infection.
Peters et al. (2021)
7 more

3 mentions without citation

The therapeutic age of the neonatal Fc receptor.
Pyzik et al. (2023)
2 more