› 6inn

X-ray diffraction
3Å resolution

Crystal structure of the CysR-CTLD3 fragment of human MR at acidic pH (pH 5.6)

Released:
DOI: 10.2210/pdb6inn/pdb
PDB entry 6inn coloured by chain, front view.
PDB entry 6inn coloured by chain, side view.
PDB entry 6inn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of the pH-dependent conformational change of the N-terminal region of human mannose receptor/CD206.
Hu Z, Wang Y, Cheng C, He Y
J Struct Biol 208 107384 (2019)
PMID: 31491467

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149836 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage mannose receptor 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 614 amino acids
Theoretical weight: 70.96 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P22897 (Residues: 22-629; Coverage: 42%)
Gene names: CLEC13D, CLEC13DL, MRC1, MRC1L1
Sequence domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 36 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NFPSS BEAMLINE BL18U
Spacegroup: P4
Unit cell:
a: 235.867Å b: 235.867Å c: 129.483Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.256 0.256 0.278
Expression system: Trichoplusia ni

Quick links

Citations

3 review citations

Macrophage Activation Markers, CD163 and CD206, in Acute-on-Chronic Liver Failure.
Nielsen et al. (2020)
2 more

1 mention without citation

Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206.
Feinberg et al. (2021)