› 6ioz

X-ray diffraction
3.1Å resolution

Structural insights of idursulfase beta

Released:
DOI: 10.2210/pdb6ioz/pdb
PDB entry 6ioz coloured by chain, front view.
PDB entry 6ioz coloured by chain, side view.
PDB entry 6ioz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kim H, Kim D, Hong J, Lee K, Seo J, Oh BH

Function and Biology Details

Reaction catalysed: 
Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149587 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Iduronate 2-sulfatase Chain: A
Molecule details ›
Chain: A
Length: 517 amino acids
Theoretical weight: 58.62 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P22304 (Residues: 34-550; Coverage: 99%)
Gene names: IDS, SIDS
Sequence domains: Sulfatase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand CA 1 x CA
Ligand NAG 2 x NAG
1 modified residue:
Ligand ALS 1 x ALS

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 11C
Spacegroup: P3112
Unit cell:
a: 70.825Å b: 70.825Å c: 285.697Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.197 0.243
Expression system: Cricetulus griseus

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