› 6ir0

Solution NMR

Zinc finger domain of the human DTX protein

Released:
DOI: 10.2210/pdb6ir0/pdb
PDB entry 6ir0 coloured by chain, ensemble of 20 models, front view.
PDB entry 6ir0 coloured by chain, ensemble of 20 models, side view.
PDB entry 6ir0 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Zinc finger domain of the human DTX protein adopts a unique RING fold.
Miyamoto K, Fujiwara Y, Saito K
Protein Sci 28 1151-1156 (2019)
PMID: 30927328

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183194 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable E3 ubiquitin-protein ligase DTX2 Chain: A
Molecule details ›
Chain: A
Length: 76 amino acids
Theoretical weight: 8.18 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q86UW9 (Residues: 399-474; Coverage: 12%)
Gene names: DTX2, KIAA1528, RNF58
Sequence domains: Zinc finger, C3HC4 type (RING finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 9%
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

2 review citations

Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease.
Wang et al. (2021)
1 more

2 mentions without citation

Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases.
Chatrin et al. (2020)
1 more