Function and Biology Details
Reaction catalysed:
S-adenosyl-L-methionine + a 5-(N(7)-methyl 5-triphosphoguanosine)-2'-O-methyladenosine-[mRNA] = S-adenosyl-L-homocysteine + a 5-(N(7)-methyl 5-triphosphoguanosine)-N(6),2'-O-dimethyladenosine-[mRNA]
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190622 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase
Molecule details ›
Chains: A, B
Length: 508 amino acids
Theoretical weight: 59.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Phosphorylated CTD interacting factor 1 WW domain
Length: 508 amino acids
Theoretical weight: 59.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q9H4Z3 (Residues: 174-672; Coverage: 71%)
Sequence domains: Phosphorylated CTD interacting factor 1 WW domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SPRING-8 BEAMLINE BL41XU
Spacegroup:
P212121
Expression system: Escherichia coli BL21(DE3)
