› 6j44

X-ray diffraction
2.06Å resolution

Crystal structure of the redefined DNA-binding domain of human XPA

Released:
DOI: 10.2210/pdb6j44/pdb
PDB entry 6j44 coloured by chain, front view.
PDB entry 6j44 coloured by chain, side view.
PDB entry 6j44 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural characterization of the redefined DNA-binding domain of human XPA.
Lian FM, Yang X, Yang W, Jiang YL, Qian C
Biochem Biophys Res Commun 514 985-990 (2019)
PMID: 31092331

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149868 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA repair protein complementing XP-A cells Chain: A
Molecule details ›
Chain: A
Length: 145 amino acids
Theoretical weight: 17.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23025 (Residues: 98-239; Coverage: 52%)
Gene names: XPA, XPAC
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P3
Unit cell:
a: 66.982Å b: 66.982Å c: 35.462Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.202 0.239
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search.
Beckwitt et al. (2020)
2 more

1 mention without citation

The XPA Protein-Life under Precise Control.
Krasikova et al. (2022)