› 6j67

X-ray diffraction
2.05Å resolution

Crystal structure of the compound 34 in a complex with TRF2

Released:
DOI: 10.2210/pdb6j67/pdb
PDB entry 6j67 coloured by chain, front view.
PDB entry 6j67 coloured by chain, side view.
PDB entry 6j67 coloured by chain, top view.
Source organisms:
Primary publication:
Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction.
Chen X, Liu L, Chen Y, Yang Y, Yang CY, Guo T, Lei M, Sun H, Wang S
ACS Med Chem Lett 9 507-511 (2018)
PMID: 29795768

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166915 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Telomeric repeat-binding factor 2 Chain: A
Molecule details ›
Chain: A
Length: 204 amino acids
Theoretical weight: 23.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15554 (Residues: 84-287; Coverage: 38%)
Gene names: TERF2, TRBF2, TRF2
Sequence domains: Telomere repeat binding factor (TRF)
Structure domains: Telomere repeat-binding factor, dimerisation domain
3FB-PHE-B8R-LEU-5XU-PRO Chain: C
Molecule details ›
Chain: C
Length: 6 amino acids
Theoretical weight: 863 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P42212
Unit cell:
a: 95.235Å b: 95.235Å c: 66.979Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.2 0.222
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

3 review citations

Targeting telomeres: advances in telomere maintenance mechanism-specific cancer therapies.
Gao et al. (2022)
2 more