› 6j6x

X-ray diffraction
2.96Å resolution

Crystal structure of apo GGTaseIII

Released:
DOI: 10.2210/pdb6j6x/pdb
PDB entry 6j6x coloured by chain, front view.
PDB entry 6j6x coloured by chain, side view.
PDB entry 6j6x coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Goto-Ito S, Yamagata A, Sato Y, Fukai S

Function and Biology Details

Reaction catalysed: 
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156829 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein prenyltransferase alpha subunit repeat-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 366 amino acids
Theoretical weight: 42.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7Z6K3 (Residues: 1-327, 328-339; Coverage: 84%)
Gene name: PTAR1
Sequence domains: Protein prenyltransferase alpha subunit repeat
Geranylgeranyl transferase type-2 subunit beta Chain: B
Molecule details ›
Chain: B
Length: 336 amino acids
Theoretical weight: 37.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53611 (Residues: 1-331; Coverage: 100%)
Gene names: GGTB, RABGGTB
Sequence domains: Prenyltransferase and squalene oxidase repeat

Ligands and Environments

2 bound ligands:
Ligand MPD 2 x MPD
Ligand MG 1 x MG
1 modified residue:
Ligand CAS 2 x CAS

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P6522
Unit cell:
a: 88.54Å b: 88.54Å c: 647.581Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.267 0.266 0.298
Expression system: Escherichia coli

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