› 6jat

X-ray diffraction
2.71Å resolution

Crystal structure of SETD3 bound to Actin peptide and SFG

Released:
DOI: 10.2210/pdb6jat/pdb
PDB entry 6jat coloured by chain, front view.
PDB entry 6jat coloured by chain, side view.
PDB entry 6jat coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Li H, Zheng Y

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N(tau)-methyl-L-histidine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159072 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Actin-histidine N-methyltransferase Chains: A, C
Molecule details ›
Chains: A, C
Length: 499 amino acids
Theoretical weight: 57.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86TU7 (Residues: 1-498; Coverage: 84%)
Gene names: C14orf154, SETD3
Sequence domains:
Actin, gamma-enteric smooth muscle Chains: B, D
Molecule details ›
Chains: B, D
Length: 22 amino acids
Theoretical weight: 2.57 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P63267 (Residues: 61-82; Coverage: 6%)
Gene names: ACTA3, ACTG2, ACTL3, ACTSG

Ligands and Environments


Cofactor: Ligand SFG 2 x SFG
2 bound ligands:
Ligand SO4 5 x SO4
Ligand EPE 1 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 60.434Å b: 131.282Å c: 175.153Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.243
Expression systems:
  • Escherichia coli
  • Not provided

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