› 6jbj

Electron Microscopy
3.6Å resolution

Cryo-EM structure of human lysosomal cobalamin exporter ABCD4

Released:
DOI: 10.2210/pdb6jbj/pdb
PDB entry 6jbj coloured by chain, front view.
PDB entry 6jbj coloured by chain, side view.
PDB entry 6jbj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of human lysosomal cobalamin exporter ABCD4.
Xu D, Feng Z, Hou WT, Jiang YL, Wang L, Sun L, Zhou CZ, Chen Y
Cell Res 29 1039-1041 (2019)
PMID: 31467407
Related structures: EMD-9791

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + vitamin B12-[cobalamin-binding protein](Side 1) = ADP + phosphate + vitamin B12(Side 2) + [cobalamin-binding protein](Side 1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127052 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysosomal cobalamin transporter ABCD4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 648 amino acids
Theoretical weight: 73.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O14678 (Residues: 2-606; Coverage: 100%)
Gene names: ABCD4, PXMP1L
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ATP 2 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-9791
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Structures of ABC transporters: handle with care.
Lewinson et al. (2020)
2 more

5 mentions without citation

Structural and functional diversity calls for a new classification of ABC transporters.
Thomas et al. (2020)
4 more