› 6jcs

Electron Microscopy
3.18Å resolution

AAV5 in complex with AAVR

Released:
DOI: 10.2210/pdb6jcs/pdb
PDB entry 6jcs coloured by chain, front view.
PDB entry 6jcs coloured by chain, side view.
PDB entry 6jcs coloured by chain, top view.
Source organisms:
Primary publication:
Divergent engagements between adeno-associated viruses with their cellular receptor AAVR.
Zhang R, Xu G, Cao L, Sun Z, He Y, Cui M, Sun Y, Li S, Li H, Qin L, Hu M, Yuan Z, Rao Z, Ding W, Rao Z, Lou Z
Nat Commun 10 3760 (2019)
PMID: 31434885
Related structures: EMD-9796

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 120-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184966 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Capsid protein Chain: A
Molecule details ›
Chain: A
Length: 516 amino acids
Theoretical weight: 58.21 KDa
Source organism: adeno-associated virus 5
UniProt:
  • Canonical: Q9YIJ1 (Residues: 209-724; Coverage: 71%)
Gene names: VP1, cap
Sequence domains: Parvovirus coat protein VP2
Dyslexia-associated protein KIAA0319-like protein Chain: R
Molecule details ›
Chain: R
Length: 97 amino acids
Theoretical weight: 10.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IZA0 (Residues: 305-401; Coverage: 9%)
Gene names: AAVR, KIAA0319L, KIAA1837, PP791

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.18Å
Relevant EMDB volumes: EMD-9796
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Adipose Tissue: An Emerging Target for Adeno-associated Viral Vectors.
Bates et al. (2020)
5 more

2 mentions without citation

Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry.
Large et al. (2021)
1 more