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› 6jeg

X-ray diffraction
2.98Å resolution

Crystal structure of calcium free human gelsolin amyloid mutant G167R

Released:
DOI: 10.2210/pdb6jeg/pdb
Model geometry
Fit model/data
PDB entry 6jeg coloured by chain, front view.
PDB entry 6jeg coloured by chain, side view.
PDB entry 6jeg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The role of gelsolin domain 3 in familial amyloidosis (Finnish type).
Zorgati H, Larsson M, Ren W, Sim AYL, Gettemans J, Grimes JM, Li W, Robinson RC
OpenAccess logo Proc Natl Acad Sci U S A 116 13958-13963 (2019)
PMID: 31243148

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139018 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gelsolin Chains: A, B
Molecule details ›
Chains: A, B
Length: 729 amino acids
Theoretical weight: 80.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06396 (Residues: 54-782; Coverage: 97%)
Gene name: GSN
Sequence domains: Gelsolin repeat

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P4212
Unit cell:
a: 172.274Å b: 172.274Å c: 150.112Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.237
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Report of two pedigrees with heterozygous HTRA1 variants-related cerebral small vessel disease and literature review.
Zhou et al. (2022)
10 other articles

1 mention without citation

The role of gelsolin domain 3 in familial amyloidosis (Finnish type).
Zorgati et al. (2019)