› 6jfl

X-ray diffraction
2.81Å resolution

Nucleotide-free Mitofusin2 (MFN2)

Released:
DOI: 10.2210/pdb6jfl/pdb
PDB entry 6jfl coloured by chain, front view.
PDB entry 6jfl coloured by chain, side view.
PDB entry 6jfl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset.
Li YJ, Cao YL, Feng JX, Qi Y, Meng S, Yang JF, Zhong YT, Kang S, Chen X, Lan L, Luo L, Yu B, Chen S, Chan DC, Hu J, Gao S
Nat Commun 10 4914 (2019)
PMID: 31664033

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131820 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitofusin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 438 amino acids
Theoretical weight: 49.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95140 (Residues: 22-757; Coverage: 57%)
Gene names: CPRP1, KIAA0214, MFN2
Sequence domains: Dynamin family

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P21
Unit cell:
a: 84.482Å b: 128.424Å c: 91.329Å
α: 90° β: 106.27° γ: 90°
R-values:
R R work R free
0.211 0.207 0.283
Expression system: Escherichia coli

Quick links

Citations

24 review citations

Regulation of Mammalian Mitochondrial Dynamics: Opportunities and Challenges.
Yu et al. (2020)
23 more

1 mention without citation

Modulating mitofusins to control mitochondrial function and signaling.
Zacharioudakis et al. (2022)