› 6jfm

X-ray diffraction
2.09Å resolution

Mitofusin2 (MFN2)_T111D

Released:
DOI: 10.2210/pdb6jfm/pdb
PDB entry 6jfm coloured by chain, front view.
PDB entry 6jfm coloured by chain, side view.
PDB entry 6jfm coloured by chain, top view.
Source organism: Macaca mulatta
Primary publication:
Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset.
Li YJ, Cao YL, Feng JX, Qi Y, Meng S, Yang JF, Zhong YT, Kang S, Chen X, Lan L, Luo L, Yu B, Chen S, Chan DC, Hu J, Gao S
Nat Commun 10 4914 (2019)
PMID: 31664033

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131820 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitofusin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 438 amino acids
Theoretical weight: 49.84 KDa
Source organism: Macaca mulatta
Expression system: Escherichia coli
UniProt:
  • Canonical: O95140 (Residues: 22-757; Coverage: 57%)
Gene names: CPRP1, KIAA0214, MFN2
Sequence domains: Dynamin family

Ligands and Environments

2 bound ligands:
Ligand ACT 2 x ACT
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P21
Unit cell:
a: 44.437Å b: 126.563Å c: 79.972Å
α: 90° β: 102.46° γ: 90°
R-values:
R R work R free
0.178 0.176 0.229
Expression system: Escherichia coli

Quick links

Citations

23 review citations

Regulation of Mammalian Mitochondrial Dynamics: Opportunities and Challenges.
Yu et al. (2020)
22 more

2 mentions without citation

Mitochondrial quality control in the brain: The physiological and pathological roles.
Shen et al. (2022)
1 more