Function and Biology Details
Reactions catalysed:
5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH
5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
- Tetrahydrofolate dehydrogenase/cyclohydrolase
- Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
- Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
- NAD(P)-binding domain superfamily
- Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
- Aminoacid dehydrogenase-like, N-terminal domain superfamily
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146835 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Molecule details ›
Chains: A, B
Length: 323 amino acids
Theoretical weight: 35.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 323 amino acids
Theoretical weight: 35.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P13995 (Residues: 36-338; Coverage: 87%)
Sequence domains:
