We've built a new version of this page with an interactive 3D viewer. Try it out in beta and help us improve:

› 6jka

X-ray diffraction
2.01Å resolution

Crystal structure of metallo-beta-lactamse, IMP-1, in complex with a thiazole-bearing inhibitor

Released:
DOI: 10.2210/pdb6jka/pdb
Model geometry
Fit model/data
PDB entry 6jka coloured by chain, front view.
PDB entry 6jka coloured by chain, side view.
PDB entry 6jka coloured by chain, top view.
Source organism: Serratia marcescens
Primary publication:
Identification of the Inhibitory Compounds for Metallo-β-lactamases and Structural Analysis of the Binding Modes.
Kamo T, Kuroda K, Kondo S, Hayashi U, Fudo S, Yoneda T, Takaya A, Nukaga M, Hoshino T
Chem Pharm Bull (Tokyo) 69 1179-1183 (2021)
PMID: 34853284

Function and Biology Details

Reaction catalysed: 
a beta-lactam + H2O = a substituted beta-amino acid.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156598 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metallo-beta-lactamase IMP-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 228 amino acids
Theoretical weight: 25.02 KDa
Source organism: Serratia marcescens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52699 (Residues: 20-242; Coverage: 98%)
Sequence domains: Metallo-beta-lactamase superfamily

Ligands and Environments

3 bound ligands:
Ligand ZN 8 x ZN
Ligand BS0 2 x BS0
Ligand BQU 1 x BQU
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PHOTON FACTORY BEAMLINE AR-NE3A
Spacegroup: P212121
Unit cell:
a: 48.477Å b: 77.764Å c: 261.527Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.193 0.25
Expression system: Escherichia coli

Quick links